A majority of the land lies within the Clinton Reservoir flood pool. Deer Creek, Rock Creek and the Wakarusa River are the three main drainages into Clinton Lake that flow through the wildlife area. There is a mix of native grassland, deciduous forest and cropland dispersed throughout these drainages.

Two man-made wetland complexes are found on the wildlife area. The oldest is the Coblentz Marsh Complex, which consists of the original West Coblentz marsh and the more recent East Coblentz marsh totaling around 160 acres in 5 different pools. These are located on the north side of the Wakarusa River and immediately east of the Shawnee-Douglas county line in Douglas County. The Elk Creek Marsh complex was completed in 2008 after several years of construction. These marshes are located on the south side of the Wakarusa River and are accessed from the parking lot located at Boat Ramp #9. The complex consists of 4 different marsh pools that total approximately 300 acres when full. The largest and newest pool is just over 100 acres in size and is located within the area's seasonal Refuge. All wetland cells except the refuge marsh can be filled by pumping water out of the Wakarusa River.

Management of native grassland is very important on the Clinton Wildlife Area. Clinton has over 200 acres of historical native prairie, most all of the non-native cool season grasslands have been converted to warm season native grasses and wildflowers.

Primary species hunted on the area include deer, turkey, waterfowl, mourning dove, bobwhite quail, squirrel, and rabbit. Also, a wide array of non-game birds, mammals, reptiles, and amphibians can be found on the area or migrating through. Trapping, fishing, and wildlife viewing are also popular past times on the area.

Clinton Wildlife Area is located approximately 7 miles west of Lawrence on the upper end of Clinton Reservoir.